PRScs源代码详解以及代码步骤测试

资源内容介绍

PRScs 是一种用于计算多性状基因风险评分（Polygenic Risk Scores, PRS）的方法，特别适用于全基因组关联分析（GWAS）数据。PRScs 是 Polygenic Risk Score - Continuous Shrinkage 的缩写，它的主要特点是在计算 PRS 时引入了连续收缩（continuous shrinkage）模型，从而对多种基因变异进行联合分析。PRScs 的主要特点包括：1.贝叶斯模型： PRScs 基于贝叶斯框架，使用连续收缩先验（continuous shrinkage prior），能够动态地调整每个 SNP 的权重，从而优化 PRS 的计算。传统的 PRS 方法通常假设所有 SNP 贡献相同，而 PRScs 可以根据数据对 SNP 贡献进行加权。2. 利用外部信息： PRScs 允许使用外部信息（如 LD 参考面板）来提高 PRS 的预测能力。LD 参考面板可以是来自相同或不同人群的基因数据，这可以帮助更好地捕捉 SNP 之间的连锁不平衡（LD）结构。

SNPA1A2BETASErs9605903TC-0.0114008.117350e-03rs5746647GT-0.0079001.506482e-02rs5747999CA-0.0060008.780564e-03rs2845380AG0.0107007.281439e-03rs2247281GA0.0117006.950269e-03rs2845346CT0.0107008.055794e-03rs2845347CT0.0109008.081235e-03rs1807512TC0.0157007.313244e-03rs5748593TC0.0149008.006321e-03rs9606468TC-0.0001008.141474e-03rs4819535TC-0.0141001.285481e-02rs5748648GA-0.0156001.332198e-02rs738045GA-0.0026006.719373e-03rs7284996TC-0.0024006.794029e-03rs2385714TC-0.0004006.874436e-03rs2080203TG0.0013007.302171e-03rs2072466CT0.0163008.696611e-03rs9605155GT0.0073006.232680e-03rs874835AG0.0072006.257647e-03rs874836AG0.0078008.879284e-03rs5994031CT0.0017006.383523e-03rs2215842CT0.0012006.186549e-03rs2192431TG-0.0125009.361660e-03rs175138GA0.0016006.112273e-03rs175139CT0.0017006.389754e-03rs983305GA0.0070006.251129e-03rs9606478GA0.0125007.083495e-03rs175140TG-0.0142009.317372e-03rs1860944GA0.0071006.254516e-03rs175145AG0.0069009.162336e-03rs175147GT0.0014006.481953e-03rs16981741AG0.0023007.000574e-03rs165652TG-0.0111007.494811e-03rs165757GA-0.0108007.491395e-03rs175152AC-0.0110007.545698e-03rs165778TC-0.0139007.943691e-03rs165810CA-0.0112006.278814e-03rs2075120CT0.0044007.231686e-03rs175154AG-0.0120007.844862e-03rs165808CT-0.0128007.909581e-03rs165890TC-0.0120007.863492e-03rs2041608TG-0.0183002.498498e-02rs12169910CT-0.0187002.496346e-02rs165886GA-0.0110007.714478e-03rs165698TC-0.0118007.730399e-03rs165608GA-0.0108006.235292e-03rs165790TC-0.0117007.751493e-03rs7291500TG-0.0239002.564716e-02rs16981833CT-0.0127001.488362e-02rs7288841CT-0.0037008.702043e-03rs9606534TC-0.0056008.763210e-03rs7293026TC0.0044008.057192e-03rs8136206CA0.0017009.019501e-03rs5992587CT-0.0078007.018231e-03rs11703901CT0.0214009.072088e-03rs2003568TC0.0000011.000000e+00rs12485066GA0.0209001.051061e-02rs5992589GA-0.0046007.378499e-03rs9306242AG-0.0042007.467146e-03rs9605179AG0.0116006.892346e-03rs9618937GA-0.0049006.599555e-03rs17806382GA-0.0095001.396720e-02rs5748748TC-0.0090001.017468e-02rs5748752CT-0.0079007.205343e-03rs5748755CT-0.0063007.143204e-03rs2385785GA-0.0068009.887080e-03rs933461GA-0.0065007.121722e-03rs1981707TC0.0073007.661765e-03rs17733785TC0.0026009.725094e-03rs8137298AC0.0102009.336124e-03rs11914017TC0.0031009.597710e-03rs11089387TC0.0047006.610644e-03rs5992598CT0.0092009.295347e-03rs7287116TC0.0088009.314894e-03rs1024732GA-0.0101006.595786e-03rs5748765AC-0.0101006.429332e-03rs5748766TG0.0093009.263358e-03rs4819925CT-0.0044007.074961e-03rs2041607GA-0.0107006.562483e-03rs759076GA-0.0048006.979115e-03rs757630TC-0.0035007.746480e-03rs4819934GA0.0027001.042287e-02rs4819936GA0.0036001.063989e-02rs5992604GA-0.0088006.498714e-03rs11913227TC-0.0036001.067758e-02rs917838TC-0.0036007.449164e-03rs738031GT0.0122001.318464e-02rs4141523GT0.0039009.208064e-03rs5748829AG-0.0153001.208229e-02rs928831TC0.0040001.023028e-02rs2845394AG0.0055006.486701e-03rs2845393TG0.0046006.394297e-03rs16981964TC-0.0164001.196557e-02rs9606592TG0.0038006.377837e-03rs5748845CT-0.0178001.195167e-02rs5994155CA0.0039008.011502e-03rs5748850TG0.0049007.976223e-03rs2041629AG0.0041007.900664e-03rs4819956AC-0.0024007.093262e-03rs4819553GA0.0030008.076387e-03rs4819958AG0.0030008.027035e-03rs4819554GA0.0030007.975388e-03rs2241042AC0.0007006.542905e-03rs2241043CT0.0004006.830225e-03rs2241044AC-0.0033006.641942e-03rs2241046CT-0.0031007.439457e-03rs879577CT0.0005007.550206e-03rs879575CT0.0012007.424526e-03rs738034GA-0.0007006.566114e-03rs3827278CA-0.0061007.654511e-03rs1047929TC0.0060007.048004e-03rs7289082AG0.0066007.100149e-03rs12170331GA0.0074007.116270e-03rs974396AG0.0169001.313734e-02rs738033GT0.0059007.085175e-03rs2277830AC0.0230001.532882e-02rs3827295GA0.0146001.432176e-02rs5748875TC0.0125007.704242e-03rs5747004CA0.0155001.356256e-02rs4819558CT-0.0006007.789214e-03rs4819559AC-0.0017008.082039e-03rs5994175GT-0.0063007.212506e-03rs740422CT0.0045008.207493e-03rs1034859CA-0.0066006.737672e-03rs3788269GA0.0030002.086995e-02rs5994180AG0.0136001.522456e-02rs5994186GA-0.0087007.070144e-03rs5994187GA-0.0082007.078717e-03rs5748919CT-0.0082007.059259e-03rs1125471CA-0.0018007.634094e-03rs1076102AG0.0063006.771787e-03rs1135909TC0.0129007.692719e-03rs3171599AG0.0163007.458611e-03rs1139056AG0.0158007.360256e-03rs2231495TC-0.0123008.138434e-03rs17807317AC0.0040006.703407e-03rs1076106CA0.0032008.434644e-03rs362129GA0.0064006.754841e-03rs5748954TC0.0002005.179781e-03rs737967CT0.0044006.318521e-03rs5748965TC0.0021006.435863e-03rs5748966CT0.0044006.304054e-03rs5994213GA0.0024007.325590e-03rs5747033AG-0.0029001.935548e-02rs5748972GA0.0080001.787078e-02rs5747037GA-0.0135007.563774e-03rs9605246TC0.0121001.100845e-02rs5994231TC-0.0069009.652337e-03rs5749002GA0.0034001.308581e-02rs5749011TC-0.0129001.269083e-02rs11704699TG-0.0086001.173632e-02rs8140080GA-0.0030007.483321e-03rs4819994TC-0.0038007.404285e-03rs5747058GA0.0099006.420686e-03rs5749016CT0.0108006.388794e-03rs12160031GA0.0018009.201056e-03rs9605252CT0.0152008.713043e-03rs4819996AG0.0035007.246467e-03rs9606682TC0.0059007.270821e-03rs5994254GA-0.0092002.150560e-02rs5994256TC0.0050007.585537e-03rs9605258TG0.0005006.178407e-03rs9605259TC0.0041007.790664e-03rs9306256CT0.0043008.699312e-03rs9619055CT0.0001005.502349e-03rs9306258GA0.0050008.774706e-03rs5994258AG-0.0007006.934978e-03rs5994260AG0.0042009.077719e-03rs9617984CT-0.0016007.023637e-03rs17808489GA-0.0094009.671771e-03rs5992665AG-0.0088007.345308e-03rs5994271GA0.0074006.866937e-03rs2040692CT-0.0019006.091271e-03rs7288834GT-0.0037006.418414e-03rs4607032GT-0.0022007.158668e-03rs5992674TC0.0261001.093160e-02rs5992034GT0.0295001.107362e-02rs9618000AG0.0199001.021977e-02rs5746359CT0.0092001.527957e-02rs4819447TG-0.0399002.173061e-02rs16982354GA-0.0232003.398300e-02rs5747103CT0.0059006.658898e-03rs1860309GA0.0039006.623718e-03rs5746366AG0.0061006.524223e-03rs5747112GA0.0059006.527973e-03rs16982402TC-0.0131009.851461e-03rs2078734CT-0.0076006.283983e-03rs1859120AG-0.0036007.053859e-03rs5747122AC-0.0501003.156789e-02rs12628081AG-0.0563003.150777e-02rs5746373TC-0.0530003.168469e-02rs2895937AG-0.0040008.671582e-03rs1981533TG0.0036007.004827e-03rs2189077TC0.0069008.055680e-03rs5747132CT0.0041008.191272e-03rs5992705CA0.0105002.109130e-02rs5992707AG0.0064002.086982e-02rs5746398TC0.0078009.230557e-03rs5747164TG0.0079009.199836e-03rs1004973GA0.0077009.217288e-03rs12157361CT0.0026001.220459e-02rs5747183AG-0.0063001.229950e-02rs2522288TC0.0012001.106003e-02rs5747187CT0.0101001.306819e-02rs4819591CT0.0091001.203839e-02rs17741035TC0.0279002.448985e-02rs5746415AG0.0122001.342554e-02rs5747195AG0.0122001.338643e-02rs2522297TC0.0019006.895505e-03rs7288509AG-0.0085008.408969e-03rs1296754GA0.0077008.000025e-03rs4819594TC0.0017008.452410e-03rs9605311GA0.0021008.537382e-03rs8141657AG0.0064006.959811e-03rs5747211GA-0.0045009.886810e-03rs174301TC0.0016007.975494e-03rs174306AG0.0036006.585230e-03rs174313GT0.0027006.622651e-03rs174330TC-0.0019007.647961e-03rs2401125TG0.0019007